Abstract This study aimed to evaluate the effects of chronic use of fluoxetine on the amount of orthodontic tooth movement and tissue changes in rats. A total of 192 Wistar rats were divided into 4 groups: S, 0.9% saline solution; F, 20 mg/kg of fluoxetine; SM, 0.9% saline solution with orthodontic movement; and FM, 20 mg/kg of fluoxetine with orthodontic movement. After 30 days of daily saline or fluoxetine administration, an orthodontic device (25cN) was used to mesially displace the first molar in animals of the groups SM and FM. The animals were euthanized 2, 7, 14, and 28 days after placement of the orthodontic appliances and animals of groups S and F were euthanized at the same time. The assessment of tooth movement was made in gypsum castings, the collagen neoformation was assessed by polarization microscopy, the number of osteoclasts and root resorption were evaluated using tartrate-resistant acid phosphatase, and presence of hyalinized areas was assessed by hematoxylin-eosin staining. Fluoxetine did not affect the amount of tooth displacement, percentage of collagen, number of osteoclasts, and presence of hyalinized areas (P>0.05). There was a higher frequency of root resorption areas in the FM group than in the SM group only on the second day (P<0.05). The findings of this study show that chronic use of 20 mg/kg fluoxetine does not affect the amount of tooth movement, collagen neoformation, number of osteoclasts, or hyalinized areas and does not affect root resorption until the last day of orthodontic movement.

Resumo O conceito de vulnerabilidade considera diferentes fatores que concorrem para a exposição de indivíduos e grupos a processos de adoecimento. Neste estudo, o referido conceito foi utilizado com o objetivo de avaliar a situação da saúde de 139 mulheres residentes em oito comunidades quilombolas, localizadas em uma área de exploração mineral, nas margens do Rio Trombetas, em Oriximiná (PA). O estudo serviu-se de entrevistas individuais semiestruturadas para coleta de dados, os quais foram submetidos a uma abordagem quantitativa e analisados por meio de estatística descritiva. Embora as comunidades quilombolas sejam historicamente vulneráveis, os dados evidenciaram que as mulheres são ainda mais fragilizadas por fatores individuais, sociais e programáticos que se revelam nas dificuldades de acesso à educação, à informação, ao trabalho, à renda e à saúde. Elas necessitam, portanto, de políticas públicas especialmente adequadas à sua condição de gênero e ao seu perfil sociocultural.

Abstract Vulnerability encompass different factors that contribute to exposing individuals and groups to the illness processes. In this study, this concept was used to assess the health situation of 139 women living in eight quilombola communities located in a mining area, on the banks of the Trombetas River, in Oriximiná, Pará, Brazil. Data were collected by semi-structured individual interviews, which underwent quantitative analysis and descriptive statistics. Although quilombola communities are historically vulnerable, women are further weakened by individual, social, and programmatic factors, revealed in the poor access to education, information, work, income and health. Hence, public policies specifically suited to their gender and socio-cultural profile are needed.

Resumo O conceito de vulnerabilidade considera diferentes fatores que concorrem para a exposição de indivíduos e grupos a processos de adoecimento. Neste estudo, o referido conceito foi utilizado com o objetivo de avaliar a situação da saúde de 139 mulheres residentes em oito comunidades quilombolas, localizadas em uma área de exploração mineral, nas margens do Rio Trombetas, em Oriximiná (PA). O estudo serviu-se de entrevistas individuais semiestruturadas para coleta de dados, os quais foram submetidos a uma abordagem quantitativa e analisados por meio de estatística descritiva. Embora as comunidades quilombolas sejam historicamente vulneráveis, os dados evidenciaram que as mulheres são ainda mais fragilizadas por fatores individuais, sociais e programáticos que se revelam nas dificuldades de acesso à educação, à informação, ao trabalho, à renda e à saúde. Elas necessitam, portanto, de políticas públicas especialmente adequadas à sua condição de gênero e ao seu perfil sociocultural.

Abstract Vulnerability encompass different factors that contribute to exposing individuals and groups to the illness processes. In this study, this concept was used to assess the health situation of 139 women living in eight quilombola communities located in a mining area, on the banks of the Trombetas River, in Oriximiná, Pará, Brazil. Data were collected by semi-structured individual interviews, which underwent quantitative analysis and descriptive statistics. Although quilombola communities are historically vulnerable, women are further weakened by individual, social, and programmatic factors, revealed in the poor access to education, information, work, income and health. Hence, public policies specifically suited to their gender and socio-cultural profile are needed.

Abstract Background The early detection of vascular damage in subclinical stages of hypertensive disease may be the key point in the prevention of cardiovascular outcomes. Objectives to correlate parameters of structural vascular damage (measurement of the carotid intima-media thickness) with parameters of functional vascular damage (central hemodynamic measurements) in pre-hypertensive and hypertensive patients taking up to two classes of anti-hypertensive drugs. Methods This was a cross-sectional descriptive study conducted with a convenience sample of patients attending the Liga de Hipertensão Arterial , a multidisciplinary program for the diagnosis and treatment of systemic hypertension, of the Federal university of Goias. Patients with arrythmia, diabetes, previous cardiovascular or cerebrovascular diseases, and end-stage diseases were excluded. Carotid Doppler test, measurements of peripheral and central blood pressure by applanation tonometry (Sphygmocor®) and oscillometry (Mobil-O-Graph®) were performed. The t-test was used for comparisons and the Pearson correlation test for correlations, considering a p<0.05 statistically significant. Results twenty patients (12 women) were evaluated, mean age 53.8 ± 14.3 years. Higher values of central pulse pressure (42.9±13.9 vs. 34.7±9.6, p=0.01) and pulse wave velocity (PWV) (9.0±1.9 vs. 7.9±1.5, p=0.01) were obtained by applanation tonometry compared with oscillometry. No difference between the methods was observed for the other measures. A significant correlation was found between carotid artery intima-media thickness (CA-IMT) and PWV (r=0.659; p=0.002) by the oscillometric test, but not with applanation tonometry. No correlation was found between central hemodynamic variables and the presence of carotid artery plaques. Conclusion PWV, estimated by oscillometry, was the only central hemodynamic parameter that correlated significantly with CA-IMT in pre-hypertensive and hypertensive patients at low cardiovascular risk. International Journal of Cardiovascular Sciences. 2020; [online].ahead print, PP.0-0

Resumo Fundamento: Os efeitos da caminhada de longa distância sobre o sistema cardiovascular são pouco estudados. Objetivos: O objetivo geral deste estudo foi verificar esses efeitos sobre o comportamento da função diastólica e dos biomarcadores cardíacos CK-MB (massa), troponina T e NT-proBNP em atletas amadores. Método: Este estudo longitudinal realizado em 2015 avaliou os participantes nas 5 etapas seguintes: A0 (basal) antes de iniciar o percurso, e as demais, A1, A2, A3 e A4 ao final de cada dia, totalizando 244,7 km. Em todas as etapas foram dosados os biomarcadores NT-proBNP, CK-MB (massa) e troponina T. Realizou-se ecocardiograma para análise das ondas E, A e E'. Adotado p < 0,05 como significativo. Resultados: Foram avaliados 25 participantes com média de idade de 46 ± 10,5 anos e índice de massa corporal de 20,2 ± 2,3 kg/m2. Encontrou-se aumentos dos valores de NT-proBNP de A0 para A1, A2, A3 e A4 (p < 0,001), CK-MB (massa) de A0 para A2 (p < 0,001) e da onda E' de A0 para A1, A2, A3 e A4 (p < 0,001). Foram identificadas correlações entre os seguintes: CK-MB (massa) e troponina T (A1: r = 0,524, p = 0,010; A4: r = 0,413, p = 0,044); CK-MB (massa) e NT-proBNP (A4: r = 0,539, p = 0,006); e E/A e E' (A0: r = 0,603, p < 0,001; A1: r = 0,639, p < 0,001; A4: r = 0,593, p = 0,002); e correlação negativa entre CK-MB (massa) com E/A (A1: r = −0,428, p = 0,041). Conclusão: Os efeitos da atividade física intensa, prolongada e intercalada foram verificados a partir das variações significativas no comportamento da CK-MB (massa), NT-proBNP e E'. Apesar das alterações encontradas, não houve critérios sugestivos de dano ao miocárdio.

Abstract Background: The effects of long-distance walking on the cardiovascular system have been little studied. Objectives: The general objective of this study was to verify these effects on the behavior of diastolic function and the cardiac biomarkers CK-MB (mass), troponin T, and NT-proBNP, in amateur athletes. Method: This longitudinal study, conducted in 2015, evaluated participants during the following 5 stages: E0 (baseline) before starting the trajectory and the others, E1, E2, E3, and E4, at the end of each day, totaling 244.7 km. At all stages, the biomarkers NT-proBNP, CK-MB (mass), and troponin T were measured. Echocardiogram was performed to analyze the E, A and E' waves. P < 0.05 was adopted as significant. Results: The study evaluated 25 participants, with an average age of 46 ± 10.5 years and body mass index of 20.2 ± 2.3 kg/m2. Increased values were found for NT-proBNP from E0 to E1, E2, E3, and E4 (p < 0.001), CK-MB (mass) from E0 to E2 (p < 0.001), and E' wave from E0 to E1, E2, E3, and E4 (p < 0.001). Positive correlations were identified between the following: CK-MB (mass) and troponin T (E1: r = 0.524, p = 0.010; E4: r = 0.413, p = 0.044); CK-MB (mass) and NT-proBNP (E4: r = 0.539, p = 0.006); and E/A and E' (E0: r = 0.603, p < 0.001; E1: r = 0.639, p < 0.001; E4: r = 0.593, p = 0.002). A negative correlation was found between CK-MB (mass) and E/A (E1: r = −0.428, p = 0.041). Conclusion: The effects of intense, prolonged, and interspersed physical activity were verified based on significant variations in the behavior of CK-MB (mass), NT-proBNP, and the E' wave. Notwithstanding the alterations found, there were no criteria suggestive of myocardial damage

Abstract Background Changes in arterial compliance are among the first changes detectable in hypertensive syndrome. Methods with good reproducibility as compared with the gold standard for identifying such changes are desirable in clinical practice. Objectives To compare central pressure measurements and arterial stiffness obtained by two non-invasive methods (tonometry and oscillometry). Methods This was a descriptive, cross-sectional study with a convenience sample of patients with borderline hypertension or stage 1 hypertension. Peripheral and central blood pressure measurements were obtained by tonometry (SphygmoCor®), considered the gold standard, and oscillometry (Mobil O´graph®). Comparisons of results were made by unpaired t-test, and p values < 0.05 were considered statistically significant. Results No difference was found in central pressure measurements obtained by SphygmoCor® (117 x 80.1 mmHg) compared with Mobil O’graph (112 x 81.4 mmHg). Mean augmentation index (AIx) was 26.1% and 21.3%, and mean pulse pressure (PP) amplification 10.7 mmHg and 10.0 mmHg by Sphygmocor® and Mobil O´graph®, respectively (p > 0.05). Mean pressure wave velocity (PWV), 8.4 m/s vs. 7.4 m/s (p = 0.013) and mean central pulse pressure, 37.7 mmmHg and 30.9 mmHg (p = 0.013) were significantly higher by SphygmoCor® than Mobil O´graph®. Conclusion Values of central systolic blood pressure, AIx and pulse pressure amplification obtained by oscillometry were not statistically different compared with tonometry; values of PWV and cPP, however, were underestimated by oscillometry. (Int J Cardiovasc Sci. 2020; 33(2):145-150)

Resumo Fundamento Os efeitos da redução na ingestão do sal sobre a pressão arterial (PA) casual de hipertensos já foram amplamente estudados, entretanto essa análise ainda é escassa no contexto da redução exclusiva do sal de adição na rigidez arterial e em indivíduos normotensos e pré-hipertensos. Objetivo Avaliar os efeitos da redução progressiva na ingestão do sal de adição (de 6 para 4 g/dia) sobre os valores da pressão periférica e central, a rigidez arterial em normotensos, pré-hipertensos e hipertensos. Métodos Ensaio clínico, simples cego com 13 semanas de seguimento. Foram avaliados normotensos (≤130/85 mmHg), pré-hipertensos (≥130 e <139/≥85 e <90 mmHg) e hipertensos estágio 1 (≥140 e <160/≥90 e <100 mmHg). Utilizou-se medida casual e monitorização residencial da PA com aparelho automático OMRON 705CP, medida central da PA com Sphygmocor®, dosagem do sódio urinário de 24h (colhido no intervalo entre cada visita) e mensuração de sal de adição. Foi adotado nível de significância p<0,05 para todas as análises. Resultados Foram avaliados 55 participantes (18 normotensos; 15 pré-hipertensos; 22 hipertensos) com mediana 48 anos (IQ:39-54). Os grupos foram semelhantes em relação a idade e sexo. Não houve diferença entre medidas de PA e excreção de sódio antes e depois da intervenção. Os parâmetros de rigidez arterial também não sofreram alterações significativas. Conclusão A redução gradativa da ingestão de sal de adição num seguimento de 13 semanas não foi capaz de reduzir de maneira significativa os valores periféricos e centrais da PA. (Arq Bras Cardiol. 2020; 114(3):554-561)

Abstract Background Although the effects of salt intake reduction on casual blood pressure have been extensively studied in hypertensive individuals, data on reductions of added salt on arterial stiffness in both normotensive and prehypertensive subjects are scarce. Objective To evaluate the effects of progressive reduction in added salt intake (from 6 grams to 4 grams per day) on peripheral and central blood pressure and arterial stiffness in normotensive, prehypertensive and hypertensive individuals. Methods This was a single-blinded clinical trial with 13 weeks of follow-up. Normotensive (≤ 130/85 mmHg), prehypertensive (≥ 130 e < 139/≥ 85 e < 90 mmHg) and stage 1 hypertensive individuals (< 139/≥ 85 and < 90 mmHg) were assessed. Casual blood pressure measurements and ambulatory blood pressure monitoring were performed using the automated OMRON 705CP device, and central blood pressure was measured using the Sphygmocor®. Twenty-four-hour urinary sodium excretion and the amounts of added salt consumed were measured. Statistically significance level was set at p < 0.05 for all analysis. Results A total of 55 participants (18 normotensive, 15 prehypertensive and 22 hypertensive), median age 48 years (IQR:39-54) were studied. The groups were not different in age or sex. No difference was observed in blood pressure or sodium excretion levels before and after the intervention. No significant changes in arterial stiffness parameters were observed. Conclusion The progressive reduction in added salt intake during a period of 13 weeks did not cause significant reductions in peripheral and central blood pressure. (Arq Bras Cardiol. 2020; 114(3):554-561)

ABSTRACT In this work, two catalysts were produced to be used in hydrolysis of cellulose reactions to obtain glucose, a raw material used in the production of bioethanol. The heteropoly acid, H3PW12O40 (HPW), reported as strong and thermally stable acid, was supported on activated carbon (AC) in a ratio varying from 1:1 to 2:1 to produce the catalysts AC-HPW (1:1) and AC-HPW (2:1). The catalysts were tested in cellulose hydrolysis evaluating some reaction variables and the results show the remarkable dependence of reaction temperature, amount and acidity of the catalyst. The results indicate the advantage of supporting HPW on carbonaceous material for using as catalyst in hydrolysis of cellulose, showing better conversion rate into sugars comparing with unsupported HPW.

ABSTRACT Heteropoly salts containing different numbers of vanadium atoms (K4[PVW11O40] - KPWV1 and K6[PV3W9O40] - KPWV3) were synthesized from the heteropoly acid H3PW12O40 (HPW), and used as catalysts in hydrolysis of cellulose reactions in order to change the redox properties and verify whether the cluster of catalysts are involved in mechanism reaction. The hydrolysis reactions following a full 23 factorial design with the variables: mass ratio (catalyst/substrate), reaction time and temperature. The variables evaluated were significant at a 90% confidence level including second and third order interactions. According to the conducted experiments, the catalysts were all active in hydrolysis. The best results occurred when HPW was used suggesting that the redox properties did not have much influence in depolymerization of cellulose and the hydrolysis mechanism are assigned to acidic properties of the medium. The main products obtained from the reactions were glucose and HMF, which are products of great interest in the chemical industry.

RESUMO Carvões ativados em forma de briquetes foram preparados a partir do resíduo da madeira de candeia, gerado no processo de extração do óleo α-bisabolol. O material foi briquetado, carbonizado e ativado com CO2,variando-se a temperatura (700-900°C) e o tempo de ativação (1-3 horas). Para a caracterização dos carvões ativados foram realizadas análise elementar (CHN-O), análise dos grupos funcionais (titulação de Boehm), bur-off, área superficial BET estimada, índice de iodo, cálculo de área superficial com azul de metileno SAM, testes de adsorção com azul de metileno e fenol e índice de resistência mecânica. Os resultados mostraram que, com o aumento da temperatura e do tempo de ativação, ocorre aumento da área superficial, do volume de poros, da basicidade do carvão e da capacidade de adsorção de azul de metileno e de fenol.

ABSTRACT ThisActivated carbons briquette shaped were prepared from Candeia wood waste, generated in the extraction of α-bisabolol oil process. The material was briquetted, carbonized and activated with CO2, varying the temperature (700-900°C) and activation time (1-3 hours). The characterization of the activated carbons were performed by: elemental analysis (CHN-O), analysis of the functional groups (Boehm titration), Burn-off, estimated BET surface area, iodine index, calculation of surface area with methylene blue, adsorption tests with methylene blue (MB) and phenol and mechanical resistance (IRI).The results showed that increasing temperature and time of activation promoted an increased in the surface area, pore volume, basicity and adsorption capacity of AM and phenol.

RESUMO O consórcio de milho com adubo verde perene é uma opção para promover a cobertura do solo, controlar plantas espontâneas e reciclar nutrientes do solo, em sistema orgânico. Objetivou-se avaliar as características agronômicas e produtividade de grãos e de palhada de milho orgânico em consórcio com adubos verdes perenes, semeados em diferentes estádios fenológicos do milho. Utilizou-se esquema fatorial 3 x 2 + 1, com três espécies perenes de adubos verdes - calopogônio (Calopogonium mucunoides Desv.), puerária [Pueraria phaseoloides (Roxb.) Benth] e soja-perene [Neonotonia wightii (Wight & Arn) Lackey] - e duas épocas de semeadura dos adubos verdes - estádios V4 (quatro folhas expandidas) e VT (pendoamento) do milho - mais um tratamento controle (milho em monocultivo). Utilizou-se delineamento em blocos casualizados, com quatro repetições. Avaliou-se a cobertura do solo, produção de massa seca dos adubos verdes e das plantas espontâneas e variáveis de crescimento e produção do milho. A semeadura dos adubos verdes, no estádio V4, proporcionou maior porcentagem de cobertura do solo, em relação ao VT. O calopogônio, quando comparado aos demais adubos verdes, apresentou maior porcentagem de cobertura do solo (35,63 %) e massa seca (1,0 Mg ha-1). Os adubos verdes perenes cultivados em consórcio com milho não interferiram no crescimento, produtividade de grãos e palhada do milho. Porém, não foram eficientes na supressão das plantas espontâneas.

ABSTRACT Maize intercropped with perennial green manure is an option to promote soil coverage, control weeds and recycle soil nutrients, in an organic system. This study aimed at evaluating the agronomic characteristics and yield of grains and organic maize straw intercropped with perennial green manures sown at different maize growth stages. A 3 x 2 + 1 factorial design was used, with three perennial species of green manure - calopogonium (Calopogonium mucunoides Desv.), tropical kudzu [Pueraria phaseoloides (Roxb.) Benth] and perennial soy [Neonotonia wightii (Wight & Arn) Lackey] - and two green manure sowing times - at the maize V4 (four expanded leaves) and VT (bolting) stages - plus a control treatment (maize monoculture). A randomized blocks design, with four replications, was used. Soil coverage, production of green manures dry matter and weeds, and maize growth and production variables were evaluated. The sowing of green manures at the V4 stage had a higher percentage of soil coverage, in relation to the VT stage. Calopogonium, when compared to the other green manure species, had the highest percentage of soil coverage (35.63 %) and dry matter (1.0 Mg ha-1). Perennial green manures grown intercropped with maize did not affect growth, grain yield and maize straw. However, they were not effective in suppressing weeds.